Genetic Epidemiology of Cancer

Genetic Epidemiology of Cancer

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This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapters are devoted to tumor biomarkers and their applicability to cancer of multiple anatomic sites. Clinical correlation will involve surveillance/management programsand focus on high-risk groups-such as those involving primary genetic or environmental factors and/or their interaction. The development of registries involving families with differing hereditary cancer syndromes are considered. Also, many chapters are devoted to environmental protective measures, as well as the need for more responsibility for coverage of patients at inordinately high risk for cancer by third party carriers. Other chapters address segregation and linkage analysis, oncogenes, cytogenetics, and other biomarkers. This book will be of interest to general clinicians, oncologists, surgeons, geneticists, and carcinogenesis investigators.I. GROWING IMPORTANCE OF GENETIC EPIDEMIOLOGY What has the genetic epidemiologic approach to cancer, the ... one would see those rapidly emerging advances in molecular biology and genetic engineering providing important clues to ... and t(8;22) (g24;g11)100%; nodular lymphomas a€“ t(14;18)(g32;g21.3); and in diffuse lymphomas a€” t(11;14)(g13.g32). ... families as investigatory models, may enable us to derive answers to cancer etiology and carcinogenesis more fully.

Title:Genetic Epidemiology of Cancer
Author: Henry T. Lynch, Takeshi Hirayama
Publisher:CRC Press - 1989-06-30

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